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KMID : 0980720180370020092
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Keimyung Medical Journal
2018 Volume.37 No. 2 p.92 ~ p.96
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Anesthetic and Perioperative Management of Patient with Paroxysmal Nocturnal Hemoglobinuria
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Choi Eun-Kyung
Kim Kwang-Beom
Park Sang-Jin
Park Ki-Bum
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Abstract
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Paroxysmal nocturnal hemoglobinuria (PNH) is a rare clonal hematopoietic stem cell disorder. Surgery, anesthesia, infection, trauma, and pregnancy can exacerbate hemolysis and thrombotic risk by increasing complement activity. However, perioperative treatment of eculizumab can reduce risk of hemolytic event by surgical stress. Here, we present the perioperative clinical course and adequate anesthetic management of PNH complicated by spine surgery under general anesthesia. We also describe a possible role of eculizumab for PNH patients with anticipated high risks.
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KEYWORD
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Hemoglobinuria, Hemolysis, Paroxysmal, Thrombosis
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